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Dr. Weinstein specializes in the
treatment of adult disc disease,
adult spinal deformities and
spondylolisthesis, spinal
stenosis, complex spinal
instrumentation, degenerative
neurospinal disorders, spinal
axis tumors, spinal cord
vascular malformations, and
spinal trauma or instability. He
also practices in the
Hydrocephalus and Shunt Program
for Adults.
Dr. Weinstein's research has
chiefly concerned repair and
regeneration after spinal cord
injury, the cerebrovascular,
cardiovascular, and metabolic
aspects of cerebral ischemia,
and mechanisms of brain
protection during temporary
focal ischemia and reperfusion.
He has used advanced magnetic
resonance imaging techniques in
the study of diffusion and
perfusion and spectroscopic
imaging to detect thresholds of
viability. More recently, he has
become involved in molecular
biologic approaches to
mechanisms of ischemic neuronal
injury in the brain and spinal
cord and the study of impairment
of blood flow regulation.
Education, Training, and
Previous Positions
1961: BA, Princeton
University
1965: MD, New York
University College of
Medicine
1965-1966: Internship, UCSF
1966-1971: Residency in
Neurological Surgery, UCSF
1971-1973: Attending
Neurosurgeon, Loma Linda
University Medical Center
1973-1977: Assistant
Professor, Neurological
Surgery, UCSF
1977-1981: Associate
Professor, Neurological
Surgery, University of
Arizona Health Sciences
Center
1980-1982: Professor,
Neurological Surgery,
University of Arizona Health
Sciences Center
1982-1984: Associate
Professor, Neurological
Surgery, UCSF
1984-present: Professor,
Neurological Surgery, UCSF
Selected Professional
Memberships and Appointments
California Medical Society
American Medical Association
California Association of
Neurological Surgeons
American College of Surgeons
Congress of Neurological
Surgeons
International Society for
the Study of Pain
American Association of
Neurological Surgeons
The Society of Neurological
Surgeons
Society for Neuroscience
Research Society of
Neurological Surgeons
International Society for
Neurovascular Surgery
International Society of
Cerebral Blood Flow and
Metabolism
Selected Honors and Awards
1976-1977: Chief Resident,
Internal Medicine, LSU, E.K.
Long Hospital
1985-1987: Clinical Fellow,
American Cancer Society
1997: Clinical Excellence
Award, Society of
Neuro-Oncology
1995-1997: Vice President,
Society of Neuro-Oncology
2004-2006: President,
Society of Neuro-Oncology
Selected Recent Publications
Acosta FL Jr, Sanai N, Chi JH,
Dowd CF, Chin C, Tihan T, Chou
D, Weinstein PR,
Ames CP. Comprehensive
management of symptomatic and
aggressive vertebral hemangiomas.
Neurosurg Clin N Am
2008;19(1):17-29.
Hong SM, Liu Z, Fan Y, Neumann
M, Won SJ, Lac D, Lum X,
Weinstein PR, Liu J.
Reduced hippocampal neurogenesis
and skill reaching performance
in adult Emx1 mutant mice. Exp
Neurol 2007;206(1):24-32.
Fan Y, Liu Z, Weinstein
PR, Fike JR, Liu J.
Environmental enrichment
enhances neurogenesis and
improves functional outcome
after cranial irradiation. Eur J
Neurosci 2007;25(1):38-46.
Liu Z, Fan Y, Won SJ, Neumann M,
Hu D, Zhou L, Weinstein
PR, Liu J. Chronic
treatment with minocycline
preserves adult new neurons and
reduces functional impairment
after focal cerebral ischemia.
Stroke 2007;38(1):146-52.
Quinones-Hinojosa A, Robert
Kolen E, Jun P, Rosenberg WS,
Weinstein PR.
Accuracy over space and time of
computer-assisted fluoroscopic
navigation in the lumbar spine
in vivo. J Spinal Disord Tech
2006;19(2):109-13.
Acosta FL Jr, Dowd CF, Chin C,
Tihan T, Ames CP,
Weinstein PR. Current
treatment strategies and
outcomes in the management of
symptomatic vertebral
hemangiomas. Neurosurgery
2006;58(2):287-95; discussion
287-95.
Guo L, Quinones-Hinojosa A,
Yingling CD, Weinstein
PR. Continuous EMG
recordings and intraoperative
electrical stimulation for
identification and protection of
cervical nerve roots during
foraminal tumor surgery. J
Spinal Disord Tech
2006;19(1):37-42.
Matsumori Y, Northington FJ,
Hong SM, Kayama T, Sheldon RA,
Vexler ZS, Ferriero DM,
Weinstein PR, Liu J.
Reduction of caspase-8 and -9
cleavage is associated with
increased c-FLIP and increased
binding of Apaf-1 and Hsp70
after neonatal hypoxic/ischemic
injury in mice overexpressing
Hsp70. Stroke 2006;37(2):507-12.
Matsumori Y, Hong SM, Fan Y,
Kayama T, Hsu CY,
Weinstein PR, Liu J.
Enriched environment and spatial
learning enhance hippocampal
neurogenesis and salvages
ischemic penumbra after focal
cerebral ischemia. Neurobiol Dis
2006;22(1):187-98.
Binder DK, Sarkissian V, Dillon
WP, Weinstein PR.
Spontaneous intracranial
hypotension associated with
transdural thoracic osteophyte
reversed by primary dural repair
[Case report]. J Neurosurg Spine
2005;2(5):614-8.
Acosta FL Jr, Thompson TL,
Campbell S, Weinstein PR,
Ames CP. Use of intraoperative
isocentric C-arm 3D fluoroscopy
for sextant percutaneous pedicle
screw placement: case report and
review of the literature. Spine
J 2005;5(3):339-43.
Quinones-Hinojosa A, Lyon R,
Zada G, Lamborn KR, Gupta N,
Parsa AT, McDermott MW,
Weinstein PR. Changes
in transcranial motor evoked
potentials during intramedullary
spinal cord tumor resection
correlate with postoperative
motor function. Neurosurgery
2005;56(5):982-93; discussion
982-93.
Matsumori Y, Hong SM, Aoyama K,
Fan Y, Kayama T, Sheldon RA,
Vexler ZS, Ferriero DM,
Weinstein PR, Liu J.
Hsp70 overexpression sequesters
AIF and reduces neonatal
hypoxic/ischemic brain injury. J
Cereb Blood Flow Metab
2005;25(7):899-910.
Suh SW, Fan Y, Hong SM, Liu Z,
Matsumori Y, Weinstein
PR, Swanson RA, Liu J.
Hypoglycemia induces transient
neurogenesis and subsequent
progenitor cell loss in the rat
hippocampus. Diabetes
2005;54(2):500-9.
Content
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